• Mactra (Spisula) J. E. Gray, 1837 accepted as Spisula J. E. Gray, 1837
• Mactra (Spisula) asperaeformis Nomura & Zinbo, 1934 † accepted as Oxyperas (Rugosoxyperas) asperaeformis (Nomura & Zinbo, 1934) †
• Mactra (Spisula) grayana Schrenck, 1867 accepted as Mactromeris polynyma (W. Stimpson, 1860)
• Mactra (Spisula) subtruncata (da Costa, 1778) accepted as Spisula subtruncata (da Costa, 1778)
• Mactra (Spisula) subtruncata var. caudata Sacco, 1901 † (uncertain > unassessed)
• Mactra (Spisula) subtruncata var. parvolaevis Sacco, 1901 † (uncertain > unassessed)
• Spisula J. E. Gray, 1837
• Spisula (Austromactra) Iredale, 1930 accepted as Austromactra Iredale, 1930
• Spisula (Austromactra) compressa (Deshayes, 1832) † accepted as Austromactra compressa (Deshayes, 1832) †
• Spisula (Austromactra) contortula (Deshayes, 1857) † accepted as Austromactra contortula (Deshayes, 1857) †
• Spisula (Austromactra) lamberti (Deshayes, 1857) † accepted as Austromactra lamberti (Deshayes, 1857) †
• Spisula (Austromactra) laudunensis (Watelet, 1853) † accepted as Austromactra laudunensis (Watelet, 1853) †
• Spisula (Austromactra) loustauae (Bayan, 1873) † accepted as Austromactra loustauae (Bayan, 1873) †
• Spisula (Austromactra) parameces (Cossmann, 1886) † accepted as Austromactra parameces (Cossmann, 1886) †
• Spisula (Austromactra) recondita (Deshayes, 1857) † accepted as Austromactra recondita (Deshayes, 1857) †
• Spisula (Austromactra) semisulcata (Lamarck, 1805) † accepted as Austromactra semisulcata (Lamarck, 1805) †
• Spisula (Crassula) Marwick, 1948 accepted as Crassula Marwick, 1948
• Spisula (Crassula) aequilateralis (Deshayes, 1854) accepted as Crassula aequilatera (Reeve, 1854)
• Spisula (Crepispisula) Eames, 1957 † accepted as Scissodesma (Crepispisula) Eames, 1957 † represented as Scissodesma Gray, 1837
• Spisula (Crepispisula) amekiensis Eames, 1957 † accepted as Scissodesma amekiensis (Eames, 1957) †
• Spisula (Hemimactra) Swainson, 1840 represented as Spisula J. E. Gray, 1837
• Spisula (Hemimactra) alaskana Dall, 1924 accepted as Spisula alaskana Dall, 1924 accepted as Mactromeris polynyma (W. Stimpson, 1860)
• Spisula (Hemimactra) chesapeakensis Glenn, 1904 † (uncertain > unassessed)
• Spisula (Hemimactra) craspedota J. A. Gardner, 1928 † represented as Spisula craspedota J. A. Gardner, 1928 †
• Spisula (Hemimactra) curtidens Dall, 1898 † accepted as Leptomactra curtidens (Dall, 1898) †
• Spisula (Hemimactra) delumbis (Conrad, 1832) † accepted as Leptomactra delumbis (Conrad, 1832) †
• Spisula (Hemimactra) densa Dall, 1898 † (uncertain > unassessed)
• Spisula (Hemimactra) dodona Dall, 1898 † accepted as Leptomactra dodona (Dall, 1898) †
• Spisula (Hemimactra) duplinensis Dall, 1898 † (uncertain > unassessed)
• Spisula (Hemimactra) harrisi Olsson, 1914 † accepted as Leptomactra harrisi (Olsson, 1914) †
• Spisula (Hemimactra) magnoliana Dall, 1898 † (uncertain > unassessed)
• Spisula (Hemimactra) marylandica Dall, 1898 † accepted as Leptomactra marylandica (Dall, 1898) †
• Spisula (Hemimactra) polymyma (W. Stimpson, 1860) accepted as Mactromeris polynyma (W. Stimpson, 1860)
• Spisula (Hemimactra) polymyma alaskana Dall, 1894 accepted as Mactromeris polynyma (W. Stimpson, 1860)
• Spisula (Hemimactra) similis (Say, 1822) accepted as Spisula solidissima similis (Say, 1822) accepted as Spisula solidissima (Dillwyn, 1817)
• Spisula (Hemimactra) solidissima (Dillwyn, 1817) represented as Spisula solidissima (Dillwyn, 1817)
• Spisula (Hemimactra) valhosierr J. A. Gardner, 1928 † accepted as Leptomactra valhosierr (J. A. Gardner, 1928) †
• Spisula (Mactromeris) Conrad, 1868 accepted as Mactromeris Conrad, 1868
• Spisula (Mactromeris) hemphillii (Dall, 1894) accepted as Mactromeris hemphillii (Dall, 1894)
• Spisula (Mactromeris) longa del Río, 1994 † accepted as Mactromeris longa del Río, 1994 †
• Spisula (Mactromeris) polynyma W. Stimpson, 1860 accepted as Mactromeris polynyma (W. Stimpson, 1860)
• Spisula (Notospisula) Iredale, 1930 accepted as Spisula J. E. Gray, 1837
• Spisula (Notospisula) austini Lamprell & Whitehead, 1990 accepted as Spisula austini Lamprell & Whitehead, 1990
• Spisula (Notospisula) colganae Healy & Lamprell, 1992 accepted as Spisula trigonella (Lamarck, 1818)
• Spisula (Oxyperas) Mörch, 1853 accepted as Oxyperas Mörch, 1853
• Spisula (Oxyperas) bernardi Pilsbry, 1904 accepted as Oxyperas bernardi (Pilsbry, 1904)
• Spisula (Pseudoxyperas) Sacco, 1901 accepted as Oxyperas Mörch, 1853
• Spisula (Ruellia) Cossmann, 1913 † represented as Spisula J. E. Gray, 1837
• Spisula (Ruellia) bernayi (Cossmann, 1886) † accepted as Spisula bernayi (Cossmann, 1886) †
• Spisula (Spisula) J. E. Gray, 1837 represented as Spisula J. E. Gray, 1837
• Spisula (Spisula) fuegiensis (E. A. Smith, 1905) represented as Spisula fuegiensis (E. A. Smith, 1905)
• Spisula (Spisula) guidoi (Signorelli & F. Scarabino, 2010) represented as Spisula guidoi (Signorelli & F. Scarabino, 2010)
• Spisula (Spisula) marplatensis (Doello-Jurado, 1949) represented as Spisula marplatensis (Doello-Jurado, 1949)
• Spisula (Spisula) ovalis (J. Sowerby, 1817) represented as Spisula solida (Linnaeus, 1758)
• Spisula (Spisulina) P. Fischer, 1887 accepted as Spisula J. E. Gray, 1837
• Spisula (Spisulona) Marwick, 1948 represented as Spisula J. E. Gray, 1837
• Spisula (Spisulona) couttsi Marwick, 1948 † represented as Spisula couttsi Marwick, 1948 †
• Spisula (Spisulona) crassitesta (H. J. Finlay, 1927) † represented as Spisula crassitesta (H. J. Finlay, 1927) †
• Spisula (Spisulona) discors (J. E. Gray, 1837) represented as Spisula discors (J. E. Gray, 1837)
• Spisula (Spisulona) murchisoni (Reeve, 1854) represented as Spisula murchisoni (Reeve, 1854)
• Spisula (Symmorphomactra) Dall, 1894 accepted as Simomactra Dall, 1894
• Spisula adamsi Olsson, 1961
• Spisula adelaidae Angas, 1865 accepted as Anapella cycladea (Lamarck, 1818)
• Spisula aequilatera (Reeve, 1854) accepted as Crassula aequilatera (Reeve, 1854)
• Spisula aequilateralis (Deshayes, 1854) accepted as Crassula aequilatera (Reeve, 1854)
• Spisula aequilateralis gilberti Bartrum, 1919 † accepted as Crassula gilberti (Bartrum, 1919) †
• Spisula alaskana Dall, 1924 accepted as Mactromeris polynyma (W. Stimpson, 1860)
• Spisula aspersa (G. B. Sowerby I, 1825) accepted as Oxyperas aspersa (G. B. Sowerby I, 1825) accepted as Oxyperas aspersum (G. B. Sowerby I, 1825)
• Spisula austini Lamprell & Whitehead, 1990
• Spisula belliana W. R. B. Oliver, 1915 accepted as Oxyperas belliana (W. R. B. Oliver, 1915) accepted as Oxyperas bellianum (W. R. B. Oliver, 1915)
• Spisula bernardi Pilsbry, 1904 accepted as Oxyperas bernardi (Pilsbry, 1904)
• Spisula bernayi (Cossmann, 1886) †
• Spisula brombachensis S. Schneider & Mandic, 2014 †
• Spisula camaronis Dall, 1921 accepted as Mactromeris hemphillii (Dall, 1894)
• Spisula capillaria Conrad, 1866 † (uncertain > unassessed)
• Spisula catilliformis Conrad, 1867 accepted as Mactromeris catilliformis (Conrad, 1867)
• Spisula couttsi Marwick, 1948 †
• Spisula craspedota J. A. Gardner, 1928 †
• Spisula crassitesta (H. J. Finlay, 1927) †
• Spisula cretacea Angas, 1868 accepted as Spisula trigonella (Lamarck, 1818)
• Spisula discors (J. E. Gray, 1837)
• Spisula dolabriformis Conrad, 1867 accepted as Simomactra dolabriformis (Conrad, 1867)
• Spisula elliptica (T. Brown, 1827)
• Spisula elliptica elliptica (T. Brown, 1827) accepted as Spisula elliptica (T. Brown, 1827)
• Spisula fragilis (Gmelin, 1791) accepted as Mactra fragilis Gmelin, 1791 accepted as Mactrotoma fragilis (Gmelin, 1791)
• Spisula fuegiensis (E. A. Smith, 1905)
• Spisula guidoi (Signorelli & F. Scarabino, 2010)
• Spisula hartingi Spaink, 1958 accepted as Spisula subtruncata (da Costa, 1778)
• Spisula hemphillii (Dall, 1894) accepted as Mactromeris hemphillii (Dall, 1894)
• Spisula hemphillii orcutti Manger, 1934 accepted as Mactromeris hemphillii (Dall, 1894)
• Spisula isabelleana (A. d'Orbigny, 1841)
• Spisula lamarckii Gray, 1837 accepted as Eastonia rugosa (Helbling, 1779)
• Spisula longa Dall, 1921 accepted as Tresus nuttallii (Conrad, 1837)
• Spisula mariae A. Adams, 1856 (unaccepted > nomen nudum)
• Spisula marplatensis (Doello-Jurado, 1949)
• Spisula murchisoni (Reeve, 1854)
• Spisula ovalis (J. Sowerby, 1817) accepted as Spisula solida (Linnaeus, 1758)
• Spisula ovata J. E. Gray, 1843 accepted as Cyclomactra ovata (J. E. Gray, 1843)
• Spisula packardi Dickerson, 1917 † (uncertain > unassessed)
• Spisula petitii (A. d'Orbigny, 1841)