A total of 112 species of cheilostomate Bryozoa are reported from a station in the eastern Weddell Sea, Antarctica, sampled by R.V. Polarstern cruise ANT-XXIV/2 (ANDEEP-SYSTCO). Twelve new species are described, distributed among the genera Micropora, Melicerita, Membranicellaria, Arachnopusia, Exochella, Aimulosia, Buffonellodes, Spigaleos and Reteporella, and a new genus and species are recognized in the each of the Calloporidae and Lacernidae. Four other species are reported for the first time from the Weddell Sea. The number of species (112) for a single sample is extremely high for Antarctic shelf waters.