This is a regional revision of the Coralliophilinae (Neogastropoda: Muricidae) from the southwest Pacific, based on the material collected during recent expeditions to New Caledonia (including the Coral Sea, mainland New Caledonia, and the Loyalty Islands),Vanuatu, Wallis and Futuna, Fiji and Tonga. It is the first revision of a tropical coralliophiline fauna based on large and extensive sampling, and it yielded a total of 97 coralliophiline species, 13 of them new: Coralliophila candidissima n. sp., C. bathus n. sp., C. norfolk n. sp., C. xenophila n. sp., C. cancellarioidea n. sp., Babelomurex natalabies n. sp., B. pallox n. sp., B. depressispiratus n. sp., B. macrocephalus n. sp., Hirtomurex marshalli n. sp., Mipus tonganus n. sp., M. alis n. sp., and M. boucheti n. sp. A lectotype is selected for Purpura monodonta Blainville, 1832. In addition, this survey resulted in new biogeographical records for 37 species from the southwest Pacific fauna. Regional endemicity may be as high as 17.5% (17 out of 97 species). The protoconchs of 47 species are figured by SEM. At least 68 species have planktotrophic development, while 10 species are probably lecithotrophic, either with a short pelagic phase or with a totally intracapsular development.