In this paper, two new sponge species, Semperella jiaolongae sp. nov. (Amphidiscosida, Pheronematidae) and Saccocalyx microhexactin sp. nov. (Lyssacinosida, Euplectellidae) are described based on materials from the South China Sea. Semperella jiaolongae sp. nov. is diagnosed mainly by the dermal areas present on both sides of the body, occurring together with atrial areas randomly distributed on one side, and the distinctive shape of micropentactins. Saccocalyx microhexactin sp. nov. is characterized by possession of two types of drepanocomes and one of microhexactins. An analysis based on partial sequence of the 16S rRNA gene was undertaken to show the congruence between morphological identification and phylogenetic classification of the two new species.